Nonsense‐mediated RNA decay (NMD) represents an established quality control checkpoint for gene expression that protects cells from consequences of gene mutations and errors during RNA biogenesis that lead to premature termination during translation. Characterization of NMD‐sensitive transcriptomes has revealed, however, that NMD targets not only aberrant transcripts but also a broad array of mRNA isoforms expressed from many endogenous genes. NMD is thus emerging as a master regulator that drives both fine and coarse adjustments in steady‐state RNA levels in the (...) cell. Importantly, while NMD activity is subject to autoregulation as a means to maintain homeostasis, modulation of the pathway by external cues provides a means to reprogram gene expression and drive important biological processes. Finally, the unanticipated observation that transcripts predicted to lack protein‐coding capacity are also sensitive to this translation‐dependent surveillance mechanism implicates NMD in regulating RNA function in new and diverse ways. (shrink)

There is an undercurrent to be detected in Anselm's record of the meditative experience that issued in the Ontological Argument and, although it points to a profound and perennial problem in the interpretation of religion, this undercurrent has been largely ignored. The Argument, as is well known, moves entirely within the medium of reflective meaning focused on the idea of God and, unlike the cosmological arguments of later theologians, it makes no appeal whatever to a principle of causality or to (...) the discovery of a sufficient reason for finite existence. Anselm seems to have had his own sense of what one may call the unadulterated rationalism of the Argument when, in his own words, he wondered, ‘if perhaps it might be possible to find one single argument that for its proof required no other save itself, and that by itself would suffice to prove that God really exists’. Here we are entirely within that inner chamber of the mind so dear to the Augustinian tradition, a mind from which one is to exclude all thought save that of God. The task of the one who reflects is to penetrate the inner meaning of this thought in order to discover what it implies beyond what is evident on the surface. With such an eminently rational or logical aim occupying the centre of attention, it is quite understandable that the presence of another, and quite opposed, concern should have been overlooked - Anselm's concern, namely, to transcend, as it were, the medium of thought itself, and enter into the presence of God. The reason that this concern introduces a tension in the search for a proof is that the realization of presence would seem to render proof superfluous, while the inference in an argument - especially one moving towards existence – inevitably suggests, in some sense and to some degree, the absence of what is sought for. (shrink)

Some decades ago in his intriguing book on Jonathan Edwards, Perry Miller used to great effect the device of supposing a two-fold biography of Edwards, an external one consisting of the historical record embracing the major events of his life and times, and an internal one aimed at an interpretation of the mind of Edwards and the development of his thought.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Jonathan Edwards's Philosophy of History: The Reenchantment of the World in the Age of EnlightenmentJohn E. SmithAvihu Zakai. Jonathan Edwards's Philosophy of History: The Reenchantment of the World in the Age of Enlightenment. Princeton: Princeton University Press, 2003. Pp. xvii + 348. Cloth, $49.95.Edwards's History of Redemption is the focus of this study by Avihu Zakai—Professor of History at the Hebrew University in Jerusalem. The History is a (...) series of thirty sermons Edwards preached on Isaiah 51:8 "... my righteousness shall be forever... my salvation from generation to generation." For him, it was a "new method in divinity... thrown into the form of a history"—a narrative showing God's sovereignty in redemption "from the fall of man to the end of the world."Zakai gives a comprehensive account of Edwards's view of history meant to highlight his struggle against modern beliefs threatening Christian faith (308; passim). The discussion is not limited to history, but includes most of Edwards's writing from 1720-1750 with emphasis on his opposition to the Enlightenment. Zakai cannot interpret so many works with the accuracy needed; he repeats old errors such as opposing the "head" and "heart" in the Affections and minimizing Edwards's respect for "common morality" in the ethical writings. Zakai is right in saying that Edwards insisted on God's authority over the world and history, but he puts it in such absolutistic terms that he often seems to abandon historical analysis in favor of exhortation.Zakai's best contribution is in his search for the general framework of God's redemption of the "engine" driving history (120ff.; 213ff.). He finds the answer in "seasons" of revival such as the Great Awakening. This is true, but Edwards notes other special events like the Reformation that "promoted the work of redemption" (Works, 9. 272), but are not revivals in the usual sense. For Edwards, special events are of many kinds and are identified by interpretation based on God's Providence. As Miller claimed, interpretation is essential; without it we may have a chronicle of events, but no history. Zakai seems to underestimate this point and the many problems it poses.The book strikes me as one more attempt—George Marsden's recent book, Jonathan Edwards: A Life (New Haven, 2003), is another—to rescue Edwards from "profane" interpreters like Miller who saw that Edwards learned from the Enlightenment even though he challenged many of its ideas. In my view, Edwards can well take care of himself.John E. SmithYale UniversityCopyright © 2004 Journal of the History of Philosophy, Inc.... (shrink)

Although Paton depends for his materials on virtually all of Kant's writings on moral philosophy, he makes the Grundlegung zur Metaphysik der Sitten central to his analysis. This is a wise choice and one that is defensible since Paton has set for himself the task of elucidating the categorical imperative and it is in the Grundlegung that Kant sought to grasp the supreme principle of morality and its appearance to us as a categorical imperative. Despite the fact that, as the (...) author points out on many occasions, the Grundlegung neither stresses morality from the standpoint of action, nor does it deal in detail with many significant problems, it must nevertheless always be looked upon as central to Kant's ethics just because it does deal with the supreme principle as a categorical imperative. The seemingly more authoritative Critique of Practical Reason is more definitely concerned with the larger subject of reason in its practical employment and does not deal as directly with Paton's special concern as the Grundlegung does. (shrink)

No one acquainted with the odyssey of Hegel’s thought in America can fail to take note of the progress that has been made over the past twenty-five years in the study and interpretation of his writings. New texts, new translations, and, above all, penetrating commentaries, have led to a better and more accurate understanding of Hegel’s philosophy and at the same time have served to overcome prejudices, a priori opinions about what he must have said, and plain errors in construing (...) his basic ideas. Much of the work that has made this progress possible has been done by members of the Hegel Society and contributors to The Owl. (shrink)

In this article I argue that evolutionary psychological strategies for making inferences about present-day human psychology are methodologically unsound. Evolutionary psychology is committed to the view that the mind has an architecture that has been conserved since the Pleistocene, and that our psychology can be fruitfully understood in terms of the original, fitness-enhancing functions of these conserved psychological mechanisms. But for evolutionary psychological explanations to succeed, practitioners must be able to show that contemporary cognitive mechanisms correspond to those that were (...) selected for in the environment of evolutionary adaptedness, that these present-day cognitive mechanisms are descended from the corresponding ancestral mechanisms, and that they have retained the functions of the ancestral mechanisms from which they are descended. I refer to the problem of demonstrating that these conditions obtain as “the matching problem,” argue that evolutionary psychology does not have the resources to address it, and conclude that evolutionary psychology, as it is currently understood, is therefore impossible. (shrink)

This paper addresses the question of what organisms are and therefore what kinds of biological entities qualify as organisms. For some time now, the concept of organismality has been eclipsed by the notion of individuality. Biological individuals are those systems that are units of selection. I develop a conception of organismality that does not rely on evolutionary considerations, but instead draws on development and ecology. On this account, organismality and individuality can come apart. Organisms, in my view, are as Godfrey- (...) class='Hi'>Smith puts it “essentially persisters.” I argue that persistence is underpinned by differentiation, integration, development, and the constitutive embeddedness of organisms in their worlds. I examine two marginal cases, the Portuguese Man O’ War and the honey bee colony, and show that both count as organisms in light of my analysis. Next, I examine the case of holobionts, hosts plus their microsymbionts, and argue that they can be counted as organisms even though they may not be biological individuals. Finally, I consider the question of whether other, less tightly integrated biological systems might also be treated as organisms. (shrink)

The idea of arousal as a non-specific state of activation has been implicated as an explanatory factor for many aspects of human behavior, ranging from emotional experiences to learning and memory. Critiques of this concept have highlighted that arousal is ambiguous and evidence for its role in emotion is mixed. However, contemporary emotion theories and empirical research continue to incorporate the concept of arousal in ways that fail to address its problems. Here, we review the origins of the term arousal (...) in physiology and trace how it has been translated and applied to psychology (particularly as it relates to emotion). We consider whether the construct of arousal is currently (a) consistent and (b) useful in understanding human behavior. (shrink)

This paper makes a plea for more reflexive attempts to develop and anchor the emerging concept of responsible research and innovation. RRI has recently emerged as a buzzword in science policy, becoming a focus of concerted experimentation in many academic circles. Its performative capacity means that it is able to mobilise resources and spaces despite no common understanding of what it is or should be ‘made of’. In order to support reflection and practice amongst those who are interested in and (...) using the concept, this paper unpacks understandings of RRI across a multi-disciplinary body of peer-reviewed literature. Our analysis focuses on three key dimensions of RRI that remain particularly opaque. A total of 48 publications were selected through a systematic literature search and their content was qualitatively analysed. Across the literature, RRI is portrayed as a concept that embeds numerous features of existing approaches to govern and assess emerging technologies. Our analysis suggests that its greatest potential may be in its ability to unify and provide political momentum to a wide range of long-articulated ethical and policy issues. At the same time, RRI’s dynamism and resulting complexity may represent its greatest challenge. Further clarification on what RRI has to offer in practice—beyond what has been offered to date—is still needed, as well as more explicit engagement with research and institutional cultures of responsibility. Such work may help to realise the high political expectations that are attached to nascent RRI. (shrink)

The concept of authenticity plays an important role in how people reason about objects, other people, and themselves. However, despite a great deal of academic interest in this concept, to date, the precise meaning of the term, authenticity, has remained somewhat elusive. This paper reviews the various definitions of authenticity that have been proposed in the literature and identifies areas of convergence. We then outline a novel framework that organizes the existing definitions of authenticity along two key dimensions: describing the (...) type of entity that is evaluated and describing the source of information that is consulted. We argue that this convergence across a number of papers, and more importantly, across a number of domains, reflects significant progress in articulating the meaning of authenticity. We conclude by suggesting new avenues for research in this area, with particular attention toward psychological process. (shrink)

Before dealing directly with the content of Urban's thought, there remains to be singled out one of its general traits, a grasp of which is absolutely necessary for any understanding of his thought. From the beginning, Urban's philosophy has exhibited a refusal to accept any ultimate impasse in thought. His is the understanding or irenic type of view over against the one-sided or polemic type. For him, reason is always comprehensive enough to sustain differences of opinion, and it is able, (...) if one goes deeply enough, to show the relativity of all exclusive oppositions in philosophical thought. There is an almost Hegelian passion for synthesis in his dogged attempts to get beyond certain disagreements between philosophical positions. It was his wont to regard impasses in thought as futile in the precise sense that neither side is able to refute the other simply because there is a sense in which both are right and both are wrong. Many illustrations from the writings of what might be called this "transcending" approach can be given: in History he seeks to show the two-fold nature of sufficient reason as both logical and ontological and approves of Kant's attempt to establish a mediating position beyond both; in Valuation the attempt is made to get "beyond the dichotomy of 'appreciation' and 'description' "; in Intelligible the view is taken that logical values are neither "existent" nor "subsistent" but "simply valid" which view is said to be beyond special ontological prejudices; in Humanity Urban is concerned to show that the religious tradition of the West has been beyond the ultimate antithesis of pure deity or mere humanity and that an indissoluble relation between the two has always been acknowledged and accepted; the attempt to get "beyond" occupies, of course, the whole of Beyond, and need not be singled out for special attention at this juncture. These illustrations are only a few of many; in calling attention to this general trait, however, it must not be thought that anything more is intended than the emphasizing of a singularly important feature of Urban's thought. Such a trait, howsoever clearly understood, would still leave us far from an adequate comprehension of his idealism; but without taking it into account his views will often appear to lack sharpness and conviction. All that can be said is that these are some of the disadvantages of a harmonizing or transcending position. (shrink)

For social species, having strong and high-quality social relationships is an important safety cue. Loneliness occurs when an individual perceives they have insufficient relationships resulting in feelings of lack of safety. States of perceived unsafety are linked to an increased tendency to construe ambiguous information – information lacking a unique clear interpretation – as threatening. Here, we explore whether the ambiguity of social cues of interpersonal rejection moderates effects of loneliness on feelings of rejection while undergoing social exclusion. Data were (...) collected in 2021; 144 adults completed a progressive social exclusion paradigm where they were randomly assigned to be equally included, excluded, or over-included. Social exclusion/inclusion cues became more pronounced over the course of multiple rounds of a ball-tossing game (Cyberball) resulting in a scenario where ambiguity was highest in earlier rounds and decreased over time. Participants reported feelings of loneliness prior to the task and feelings of rejection throughout the task. Results demonstrated that higher loneliness predicted increased feelings of rejection regardless of exclusion condition. Notably, this positive relationship was strongest during earlier rounds when social cues were most ambiguous. These findings contribute to our understanding of how loneliness modulates social perception to enable organisms to adequately adapt to changing circumstances. (shrink)